An airliner filled with 800 passengers is forced to fly fast and low, above farmlands, suburbs and skyscraper-packed cities or the tons of explosives aboard will detonate. When an elite unit of US Air Force fighter jets is sent to provide escort, they find themselves facing a squadron of unidentifiable warplanes which ignites a deadly air battle that threatens to destroy all life above and below.

Recent graduates of a secluded U.S. Air Force base must protect a gene-editing bioweapon from the Russian military—who are desperate to seize the deadly viral agent at any cost.